The 55-year-old actor has been cast with Eva De Dominic in the comedy drama from director Nadia Conners.
The pair join an ensemble that includes Pedro Pascal, Elizabeth Reaser, Walton Goggins and Lois Smith.
The movie has been written and directed by Conners and tells the story of how a stranger interrupts a party and provokes a comedy of errors. Kate Comer, Michael Panes, Annie Korzen and Roland Rubio round out the cast.
Rosie Fellner, Ari Taboada and Carlos Enrique Cusco are producing the film, which is currently shooting in Los Angeles.
Rufus previously starred in the medieval flick 'A Knight's Tale' and regretted his hangovers while dressed in armour.
He said: "I am very fond of that film and those memories. Me and Heath (Ledger) were very close and we did have a riotous good time. I learned that is not a pleasant experience."
The 'Hercules' star explained that wearing armour presented him with several practical challenges during the making of the 2001 movie.
He recalled: "I would pour water into it, and you would see steam come out. And working out how to smoke through my visor, that was a feat of engineering. These are the problems an actor has."
Sewell featured in M. Night Shyamalan's film 'Old' and opened up on the lengthy make-up process on the project.
He explained: "For 'Old', I would sit in a make-up chair for four hours and have them add 25 years on me and, because the make-up was so good, by the end of the day I would think that that's my face."
Sarah Michelle Gellar says she had "nobody" to help her when she was a child actor and wanted to make sure things were different for her young co-stars today.
Britney Spears is said to be "annoyed" with her fans for sending the police to her Thousand Oaks mansion to check on her after she deleted her Instagram account.
Chelsea Handler "didn't realise" she had been prescribed a weight loss drug until her friend pointed it out to her and ended up giving doses of the treatment away.
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